| Name | Team | Pos | Rush Yds | Att | Yds/ Att | Rush TD | Tackles for Loss | Fumbles | |
|---|---|---|---|---|---|---|---|---|---|
| 26 Saquon Boston | HB | 594 | 169 | 3.5 | 3 | 16 | 4 | ||
| 7 C.J. Stewart | QB | 126 | 15 | 8.4 | 0 | 22 | 0 | ||
| 37 DeWayne Moreau | HB | 61 | 22 | 2.8 | 0 | 2 | 0 | ||
| 25 Tyler Anderson | HB | 1023 | 247 | 4.1 | 7 | 28 | 1 | ||
| 34 Keaton Moore | HB | 217 | 76 | 2.9 | 0 | 8 | 1 | ||
| 25 Elijah McCown | HB | 794 | 202 | 3.9 | 8 | 15 | 2 | ||
| 36 Khalan Long | HB | 420 | 144 | 2.9 | 2 | 24 | 0 | ||
| 28 De'Von Armstrong | HB | 990 | 280 | 3.5 | 5 | 27 | 3 | ||
| 34 T.J. Singleton | HB | 2 | 2 | 1.0 | 0 | 0 | 0 | ||
| 13 Brandon Daley | QB | 5 | 1 | 5.0 | 0 | 2 | 0 | ||
| 45 Eno Blanton | HB | 121 | 49 | 2.5 | 1 | 6 | 1 | ||
| 25 Israel Adams | HB | 247 | 74 | 3.3 | 2 | 6 | 0 | ||
| 12 Ryan Potts | QB | 77 | 9 | 8.6 | 1 | 24 | 4 | ||
| 7 Geno Schneider | QB | 210 | 24 | 8.8 | 0 | 22 | 0 | ||
| 45 James Collins | HB | 651 | 164 | 4.0 | 2 | 18 | 1 | ||
| 26 Evan Henderson | HB | 596 | 160 | 3.7 | 6 | 13 | 1 | ||
| 4 Deshaun Waddle | QB | 180 | 21 | 8.6 | 1 | 27 | 1 | ||
| 1 Rachaad Williams | HB | 294 | 90 | 3.3 | 2 | 14 | 0 | ||
| 26 Zach Cowser | HB | 1024 | 275 | 3.7 | 10 | 23 | 2 | ||
| 9 Kenneth Williams | HB | 553 | 149 | 3.7 | 3 | 18 | 1 | ||
| 86 Jaret Peters | HB | 10 | 4 | 2.5 | 0 | 0 | 0 | ||
| x2 | 17 Josh Ash | QB | 228 | 29 | 7.9 | 0 | 17 | 0 | |
| x2 | 25 Samaje Peterson | HB | 146 | 45 | 3.2 | 1 | 8 | 0 | |
| x2 | 7 D'Ernest Jackson | HB | 724 | 228 | 3.2 | 10 | 28 | 1 | |
| 21 D'Onta Faulkner | HB | 836 | 252 | 3.3 | 7 | 29 | 2 | ||
| 35 Deon Jones | HB | 224 | 79 | 2.8 | 2 | 9 | 0 | ||
| 5 David Moore | HB | 808 | 196 | 4.1 | 6 | 18 | 3 | ||
| 8 Will Lemonier | QB | 179 | 18 | 9.9 | 0 | 22 | 0 | ||
| 34 Malik Dzubnar | HB | 559 | 143 | 3.9 | 3 | 10 | 1 | ||
| 1 Tua Taylor | QB | 270 | 31 | 8.7 | 4 | 43 | 1 | ||
| 25 Clyde Exum | HB | 163 | 59 | 2.8 | 4 | 7 | 1 | ||
| 36 Kevin Hobbs | HB | 896 | 237 | 3.8 | 7 | 18 | 1 | ||
| 22 Najee Hutchinson | HB | 367 | 120 | 3.1 | 0 | 13 | 1 | ||
| 35 James Richardson | HB | 985 | 278 | 3.5 | 7 | 27 | 2 | ||
| 28 A.J. Davis | HB | 816 | 236 | 3.5 | 4 | 28 | 3 | ||
| 30 Roschon Jackson | HB | 520 | 147 | 3.5 | 2 | 14 | 1 | ||
| 6 Miles Sanu | HB | 811 | 219 | 3.7 | 5 | 19 | 3 | ||
| 9 Desmond Rubio | QB | 163 | 17 | 9.6 | 2 | 15 | 0 | ||
| 22 Derrick Hunt | HB | 947 | 285 | 3.3 | 7 | 34 | 11 | ||
| 33 Aaron Jackson | HB | 432 | 134 | 3.2 | 2 | 21 | 0 | ||
| 10 Mitchell Thomas | QB | 232 | 21 | 11.0 | 0 | 51 | 8 | ||
| 31 Dameon Price | HB | 820 | 237 | 3.5 | 5 | 24 | 2 | ||
| 23 Jeff Walker | HB | 107 | 44 | 2.4 | 4 | 5 | 0 | ||
| 6 Baker McDonald | QB | 185 | 21 | 8.8 | 1 | 33 | 2 | ||
| 30 Christian Martin | HB | 879 | 256 | 3.4 | 10 | 20 | 2 | ||
| x2 | 9 Joe Brooks | QB | 225 | 26 | 8.7 | 1 | 27 | 1 | |
| 25 Tyrion Duarte | HB | 286 | 80 | 3.6 | 2 | 8 | 0 | ||
| 15 Patrick McKinney | QB | 265 | 33 | 8.0 | 2 | 39 | 2 | ||
| 28 Joe Maponga | HB | 641 | 143 | 4.5 | 1 | 11 | 2 | ||
| 26 Jahmyr Glover | HB | 631 | 171 | 3.7 | 7 | 12 | 1 | ||
| 28 Jonathan Thompson | HB | 822 | 266 | 3.1 | 4 | 40 | 4 | ||
| 22 Chase Everett | HB | 317 | 100 | 3.2 | 2 | 14 | 1 | ||
| 9 Hendon Hickman | QB | 193 | 21 | 9.2 | 1 | 48 | 4 | ||
| 38 Rhamondre Sendejo | HB | 997 | 248 | 4.0 | 6 | 17 | 2 | ||
| 24 Khalil Harris | HB | 341 | 81 | 4.2 | 2 | 5 | 1 | ||
| 20 Breece Hurst | HB | 431 | 136 | 3.2 | 1 | 13 | 0 | ||
| 14 Kenneth Green | HB | 950 | 288 | 3.3 | 7 | 29 | 2 | ||
| 7 Bijan Ramczyk | HB | 904 | 268 | 3.4 | 6 | 34 | 4 | ||
| 9 Jacoby Burse | QB | 197 | 18 | 10.9 | 3 | 34 | 0 | ||
| 42 Deuce Valenzuela | HB | 326 | 102 | 3.2 | 2 | 12 | 0 | ||
| 42 Caleb Halapio | HB | 715 | 209 | 3.4 | 5 | 21 | 0 | ||
| x4 | 4 Dak Pennel | QB | 354 | 37 | 9.6 | 1 | 47 | 4 | |
| 85 Eric Gilbert | HB | 11 | 4 | 2.8 | 0 | 0 | 0 | ||
| 25 Kenny Marsh | HB | 530 | 181 | 2.9 | 4 | 17 | 0 | ||
| 0 D'Andre Silatolu | HB | 1032 | 248 | 4.2 | 4 | 22 | 4 | ||
| 1 Justin Funchess | QB | 172 | 16 | 10.8 | 0 | 29 | 4 | ||
| 32 Michael Conner | HB | 356 | 75 | 4.7 | 6 | 5 | 0 | ||
| 24 Nick Coleman | HB | 1096 | 279 | 3.9 | 9 | 27 | 1 | ||
| 32 Trayveon Webb | HB | 339 | 101 | 3.4 | 3 | 9 | 0 | ||
| 4 Kemal Healey | QB | 6 | 1 | 6.0 | 0 | 0 | 0 | ||
| 8 Josh Jones | HB | 1030 | 282 | 3.7 | 7 | 29 | 0 | ||
| 28 Ronald Jones | HB | 582 | 143 | 4.1 | 4 | 20 | 0 | ||
| 19 Zach Wright | QB | 130 | 14 | 9.3 | 1 | 16 | 2 | ||
| 8 Brian Roberts | HB | 1438 | 318 | 4.5 | 12 | 30 | 3 | ||
| 44 Sean Taylor | HB | 598 | 147 | 4.1 | 4 | 8 | 0 | ||
| 24 Chuba Hogan | HB | 746 | 200 | 3.7 | 4 | 22 | 1 | ||
| 10 Mac Jackson | QB | 361 | 40 | 9.0 | 1 | 48 | 2 | ||
| 37 Myles Garcia | HB | 168 | 56 | 3.0 | 1 | 8 | 0 | ||
| 33 Javonte Walton | HB | 983 | 271 | 3.6 | 9 | 30 | 0 | ||
| 22 Damien Holton | HB | 415 | 119 | 3.5 | 0 | 10 | 1 | ||
| 20 Tony Phillips | HB | 941 | 263 | 3.6 | 7 | 26 | 1 | ||
| 26 Tony Jerome | HB | 503 | 107 | 4.7 | 1 | 10 | 0 | ||
| 1 Kyler Marshall | QB | 158 | 17 | 9.3 | 0 | 26 | 4 | ||
| 27 Jarron Williams | HB | 103 | 14 | 7.4 | 1 | 0 | 0 | ||
| 2 Brandon Pederson | QB | 81 | 8 | 10.1 | 0 | 7 | 1 | ||
| 35 Zamir Walker | HB | 87 | 22 | 4.0 | 0 | 2 | 0 | ||
| 7 Ryan Merrick | QB | 37 | 3 | 12.3 | 1 | 6 | 3 | ||
| 25 Demetric Flores | HB | 174 | 48 | 3.6 | 1 | 5 | 0 | ||
| 7 Malik Worley | QB | 233 | 32 | 7.3 | 1 | 51 | 1 | ||
| 27 J.K. Dawson | HB | 342 | 103 | 3.3 | 2 | 10 | 0 | ||
| x2 | 6 Jeremy Foley | QB | 116 | 12 | 9.7 | 1 | 38 | 5 | |
| 10 Justin Harrison | QB | 223 | 26 | 8.6 | 3 | 26 | 2 | ||
| 36 Julius Carter | HB | 405 | 121 | 3.3 | 2 | 19 | 0 | ||
| 30 Jaylen Wilson | HB | 136 | 31 | 4.4 | 1 | 1 | 1 | ||
| 21 Zach Everett | HB | 124 | 26 | 4.8 | 1 | 2 | 0 | ||
| 16 Trevor Lynch | QB | 92 | 12 | 7.7 | 1 | 9 | 2 | ||
| x2 | 9 Bryce Yoder | QB | 79 | 9 | 8.8 | 0 | 11 | 1 | |
| 4 Kenneth Paulino | QB | 36 | 4 | 9.0 | 0 | 2 | 0 | ||
| 7 Daniel Jacobs | QB | 90 | 10 | 9.0 | 0 | 23 | 3 | ||
| 13 Brock Penton | QB | 39 | 7 | 5.6 | 1 | 12 | 0 | ||
| 0 Jake Hansen | QB | 72 | 9 | 8.0 | 0 | 15 | 0 | ||
| 1 Jalen Harrell | QB | 216 | 23 | 9.4 | 4 | 26 | 4 | ||
| 8 Kenny Portillo | QB | 166 | 20 | 8.3 | 0 | 43 | 3 | ||
| 14 Sam Duncan | QB | 137 | 12 | 11.4 | 1 | 20 | 1 | ||
| 38 Antonio Gary | HB | 506 | 152 | 3.3 | 7 | 11 | 1 | ||
| 16 Jared Green | QB | 99 | 10 | 9.9 | 0 | 15 | 2 | ||
| 24 Nyheim Horton | HB | 37 | 18 | 2.1 | 0 | 4 | 0 | ||
| 40 Snoop Cunningham | HB | 6 | 2 | 3.0 | 0 | 0 | 0 | ||
| 8 Max Dupre | QB | 6 | 1 | 6.0 | 0 | 0 | 0 | ||
| 2 Alexander McDonald | HB | 31 | 12 | 2.6 | 0 | 1 | 0 | ||
| x2 | 15 Drew Linder | QB | 13 | 1 | 13.0 | 0 | 0 | 0 |